Corneal cross-linking: an effective treatment option for pellucid marginal degeneration.
There is a lack of evidence supporting efficacy and stability of CXL in PMD, and well-controlled prospective studies with long-term follow-up are necessary. The authors concluded that CXL seems to be safe and effective in the management of PMD, but existing literature is limited, with short-term follow-up and the retrospective nature of most studies. Management of pellucid marginal corneal degeneration. It is often confused with keratoconus because.
None of the studies reported any complications, however rare but serious potential complications can occur and should be noted. Tzelikis PF, Cohen EJ, Rapuano CJ, Hammersmith KM, Laibson PR. Pellucid marginal corneal degeneration (PMCD) is a progressive, non-inflammatory disease of the lower cornea. In the studies, CXL was performed immediately after surface ablation, theoretically combining benefits of both treatments. Combined CXL and laser vision correction demonstrated a greater improvement in uncorrected distance visual acuity (UDVA) vs. Surgical correction for PMCD provides poor long-term reduction of astigmatism. Patients with PMCD may be adequately corrected in the long term by the use of scleral fitted gas-permeable contact lenses. Four studies included follow-up duration >1 year. Management of pellucid marginal corneal degeneration Surgical correction for PMCD provides poor long-term reduction of astigmatism. CXL was shown to halt disease progression and stabilise / improve vision in all studies. All of the studies included additional treatments that were used with CXL: photorefractive keratectomy (PRK), phototherapeutic keratectomy (PTK) and intrastromal corneal ring segment (ICRS). decentered grafts closer to limbus confer a greater risk of vascularisation, suture erosion and rejection). Pellucid marginal degeneration (PMD) is a rare disorder of the peripheral cornea causing corneal thinning, generally at the inferior quadrants of the cornea. Progression of PMD is important because keratoplasty in PMD is associated with significant comorbidity (e.g. Compared to other corneal thinning conditions like keratoconus, corneal steepening in PMD occurs more inferiorly and closer to the limbus.
PMD is a bilateral, non-inflammatory corneal thinning disorder characterised by inferior peripheral corneal thinning 1-3mm from the limbus in the 4 to 8 o’clock position. Fourteen studies were included in this first review examining the use of corneal-crosslinking (CXL) to treat pellucid marginal degeneration (PMD).
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